Is the 2021 Mercedes-Benz E 350 reliable?

The 2021 Mercedes-Benz E 350 has 19 complaints filed with NHTSA (1.9x the segment average). Our reliability verdict: below-average. Most common issue: DRIVER ASSIST/CAMERAS problems.

What are common problems with the 2021 Mercedes-Benz E 350?

Top problems: DRIVER ASSIST/CAMERAS (5 complaints, avg repair $500); ENGINE (4 complaints, avg repair $500); ELECTRICAL (4 complaints, avg repair $500). Issues typically appear around 50K miles.

Are there any recalls on the 2021 Mercedes-Benz E 350?

Yes, there are 6 recall(s): FUEL SYSTEM, GASOLINE:DELIVERY:FUEL PUMP, ELECTRICAL SYSTEM:SOFTWARE, ELECTRICAL SYSTEM:SOFTWARE, BACK OVER PREVENTION: SENSING SYSTEM: CAMERA, AIR BAGS:SENSOR:SIDE IMPACT, BACK OVER PREVENTION:DISPLAY FUNCTION. Contact any Mercedes-Benz dealer to verify if recalls have been completed on your specific vehicle.

How much does it cost to fuel a 2021 Mercedes-Benz E 350?

The 2021 Mercedes-Benz E 350 gets 25 MPG combined. At current US average gas prices, driving 12,000 miles per year costs roughly $1920. See the interactive fuel cost calculator on this page for state-specific pricing.

How much does it cost to insure a 2021 Mercedes-Benz E 350?

Estimated US average full-coverage insurance for the 2021 Mercedes-Benz E 350 is approximately $2,250/year (sedan-luxury class). Actual quotes vary heavily by state, driver age, driving record, and credit — see the interactive insurance estimator on this page for state-specific pricing.

2021 Mercedes-Benz E 350

Problems, Recalls & Reliability Report

Below Average

Quick Summary

The 2021 Mercedes-Benz E 350 has 19 owner complaints filed with NHTSA — that's 1.9x the segment average of 10. The most common issue is driver assist/cameras problems (26% of all complaints), specifically: when in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. an inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. this has been happeni. There are 6 recalls issued for this model year. ⚠️ 2 fire reports filed.

2 fire reports

Total Complaints

Recalls Issued

—/5

Safety Stars

1.9x

vs Segment Avg

Known Problems(top 5 of 6)

DRIVER ASSIST/CAMERAS

5 complaints

26%

• When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happeni
• I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.
• I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.

Typical onset: 50K miles Est. repair: $500

“When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happeni”

— NHTSA complaint filing

Recalls (6)

FUEL SYSTEM, GASOLINE:DELIVERY:FUEL PUMP26/06/2023

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

Risk: A loss of drive power can increase the risk of a crash.

Fix: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

Fuel Cost Calculator for 2021 Mercedes-Benz E 350

Live EIA prices

Annual miles driven: 12,000

Your state (affects local gasoline price)

Per year

$1,920

Per month

$160

Per mile

16.0¢

MPG

City driving (worst-case MPG)

$2,182/yr

Highway driving (best-case MPG)

$1,549/yr

Based on EPA fuel-economy ratings and EIA weekly retail prices (2026-07-20). Real-world cost varies with driving style, trim/engine, terrain, and traffic.

5-Year Gas Price History

EIA weekly retail data · 2021 → today

Show:

Current

$4.00

5-year low

$2.78

5-year high

$5.01

Since 2021

+27%

Source: US Energy Information Administration weekly retail gasoline prices.

Estimated Insurance Cost for 2021 Mercedes-Benz E 350

Estimate only, not a quote. Modeled from NAIC + HLDI averages for a hypothetical 35-year-old driver with clean record + full coverage. Your actual quote depends heavily on your age, driving history, credit, ZIP code, and insurer.

Your state (affects local premium average)

Full coverage / year

$2,250

Full coverage / month

$188

Liability only / year

$710

vs US avg

+34%

How this estimate is calculated

US base full-coverage premium$1674

× state (US)1.00x

× vehicle class (sedan-luxury)1.28x

× theft risk1.00x

× safety rating1.00x

× vehicle age1.05x

= Full coverage estimate$2250

Coverage assumed: 100/300/100 liability + comprehensive/collision, $500 deductibles. Data sources: NAIC 2024 + HLDI loss studies.

Maintenance & Warranty

Recommended Mercedes-Benz E 350 Service Intervals

Oil change

10K mi / 12 mo

Tire rotation

10K mi

Brake fluid

24 months

Transmission fluid

40K mi

Engine coolant

150K mi

Spark plugs

60K mi

Cabin air filter

20K mi

Engine air filter

40K mi

Differential (AWD/4WD)

40K mi

Service A / Service B alternating schedule. Requires MB-approved oil (229.5 spec typically).

"Severe service" conditions (heavy towing, extreme temps, city stop-and-go) typically halve these intervals. Always consult your vehicle's owner's manual for the authoritative schedule.

Mercedes-Benz New-Vehicle Warranty Coverage

Bumper-to-bumper (basic)

4 yr / 50K mi

Powertrain

4 yr / 50K mi

Hybrid/EV battery

10 yr / 155K mi

Corrosion (rust perforation)

4 yr / 50K mi

Roadside assistance

4 yr / unlimited mi

EQ EV battery warranty is 10 years/155,000 miles

These are the terms for a new Mercedes-Benz. If you're buying a used 2021 E 350, remaining coverage is usually pro-rated from the vehicle's original in-service date. Not all coverage transfers between owners — check with a Mercedes-Benz dealer for VIN-specific remaining warranty.

Estimated Repair Costs

DRIVER ASSIST/CAMERAS(~50K mi)

$500

ENGINE(~50K mi)

$500

ELECTRICAL(~50K mi)

$500

FUEL SYSTEM(~50K mi)

$500

TRANSMISSION(~50K mi)

$500

Estimates based on average reported repair costs. Actual costs vary by location, shop, and severity.

🔍 Pre-Purchase Inspection Checklist

Based on 19 owner complaints for this specific year, here's what to check or ask about:

☐
DRIVER ASSIST/CAMERAS: When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happeni
Typically appears around 50K miles. Repair cost ~$500
☐
ENGINE: The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n
Typically appears around 50K miles. Repair cost ~$500
☐
ELECTRICAL: The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n
Typically appears around 50K miles. Repair cost ~$500
☐
FUEL SYSTEM: The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced.
Typically appears around 50K miles. Repair cost ~$500
☐
RECALLS: Verify all 6 recalls have been completed — free at any Mercedes-Benz dealer
☐
General: Get a pre-purchase inspection from an independent mechanic ($100-$200)