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Mercedes-Benz

2021 Mercedes-Benz E 350

Problems, Recalls & Reliability Report

Excellent Reliability

Quick Summary

The 2021 Mercedes-Benz E 350 has 19 owner complaints filed with NHTSA — that's 0.2x the segment average of 80. The most common issue is driver assist/cameras problems (26% of all complaints), specifically: when in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. an inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. this has been happeni. ⚠️ 2 fire reports filed.

2 fire reports

19

Total Complaints

0

Recalls Issued

/5

Safety Stars

0.2x

vs Segment Avg

Known Problems

DRIVER ASSIST/CAMERAS

5 complaints
26%
  • When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happeni
  • I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.
  • I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.
Typical onset: 50K miles Est. repair: $500

When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happeni

— NHTSA complaint filing

ENGINE

4 complaints
21%
  • The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n
  • FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned t
  • My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect ackn
Typical onset: 50K miles Est. repair: $500🔥 1 fire reports

The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n

— NHTSA complaint filing

ELECTRICAL

4 complaints
21%
  • The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n
  • FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned t
  • 1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driv
Typical onset: 50K miles Est. repair: $500🔥 1 fire reports

The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n

— NHTSA complaint filing

FUEL SYSTEM

3 complaints
16%
  • The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced.
  • The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n
  • Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump con
Typical onset: 50K miles Est. repair: $500

The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced.

— NHTSA complaint filing

TRANSMISSION

2 complaints
11%
  • The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.
  • With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .
Typical onset: 50K miles Est. repair: $500

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

— NHTSA complaint filing

Estimated Repair Costs

DRIVER ASSIST/CAMERAS(~50K mi)
$500
ENGINE(~50K mi)
$500
ELECTRICAL(~50K mi)
$500
FUEL SYSTEM(~50K mi)
$500
TRANSMISSION(~50K mi)
$500

Estimates based on average reported repair costs. Actual costs vary by location, shop, and severity.

🔍 Pre-Purchase Inspection Checklist

Based on 19 owner complaints for this specific year, here's what to check or ask about:

  • DRIVER ASSIST/CAMERAS: When in reverse, sometimes the rearview camera image does not come and and the parking sensors do not work. An inoperative rearview camera display and/or parking sensors can reduce the driver’s view and awareness of what is behind the vehicle, increasing the risk of a crash. This has been happeni

    Typically appears around 50K miles. Repair cost ~$500

  • ENGINE: The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n

    Typically appears around 50K miles. Repair cost ~$500

  • ELECTRICAL: The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car n

    Typically appears around 50K miles. Repair cost ~$500

  • FUEL SYSTEM: The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced.

    Typically appears around 50K miles. Repair cost ~$500

  • General: Get a pre-purchase inspection from an independent mechanic ($100-$200)

Mercedes-Benz E 350 — Year Comparison

How does 2021 compare to other years? Fewer complaints = more reliable.

Full years-to-avoid analysis →

NHTSA Safety Rating

No NHTSA safety rating available

At a Glance

Complaints
19
Recalls
0
Fire reports
2
Crash reports
0
Injury reports
0
Segment avg
80

Check a Specific VIN

See recalls for YOUR 2021 Mercedes-Benz E 350